Synergistic Approach to Combat Triple‐Negative Breast Cancer: B7‐H4 Checkpoint‐Based Photodynamic Nanodrug Coupled with Neutrophil Extracellular Trap Regulation

Abstract Triple‐negative breast cancer (TNBC) is the most aggressive subtype, which often results in distant metastasis and dismal prognosis. Unfortunately, current treatments for TNBC are not effective due to its resistance immunotherapy. Recent studies indicate that B7‐H4 immune checkpoint overexpression inflammation‐initiated neutrophil extracellular traps (NETs) closely associated with poor immunotherapy outcome of TNBC. This study finds a checkpoint‐based photodynamic nanodrug combined NETs regulation enables potent therapeutic The induces antitumor immunity via therapy, enabling cascade reinforcement target‐based outcomes. By combining DNase I nanodrug, potentiates immunotherapeutic efficacy by disrupting barrier between tumor cells T cells, reinforcing response antimetastasis efficacy. combination therapy demonstrates powerful ability suppressing growth metastasis, offering robust approach treating immune‐cold while addressing